Dr. Pascale Hazel

Publications

• Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. Hazel, P., Kroll, S.H., Bondke, A., Barbazanges, M., Patel, H., Fuchter, M.J., Coombes, R.C., Ali, S., Barrett, A.G., Freemont, P.S. ChemMedChem, 2017, 12, 372.
• A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Heathcote DA, Patel H, Kroll SH, Hazel P., Periyasamy M., Alikian M., Kanneganti SK., Jogalekar AS., Scheiper B., Barbazanges M., Blum A., Brackow J., Siwicka A., Pace RD., Fuchter MJ., Snyder JP., Liotta DC., Freemont PS., Aboagye EO., Coombes RC., Barrett AG., Ali S. J. Med. Chem., 2010, 53, 8508.
• Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Lee, M. P., Parkinson, G. N., Hazel, P., Neidle, S. J. Am. Chem. Soc., 2007, 129, 10106.
• Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. Hazel, P., Parkinson, G. N., Neidle, S. J. Am. Chem. Soc., 2006, 128, 5480.
• Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Hazel, P., Parkinson, G. N., Neidle, S. Nucleic Acids Res., 2006, 34, 2117.
• Quadruplex DNA: sequence, topology and structure. Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K., Neidle, S. Nucleic Acids Res., 2006, 34, 5402.
• Loop length-dependent folding of G-quadruplexes. Hazel, P., Huppert, J., Balasubramanian, S., Neidle, S. J. Am. Chem. Soc., 2004, 126, 16405.
• Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Guyen, B., Schultes, C. M., Hazel, P., Mann, J., Neidle, S. Org. Biomol. Chem., 2004, 2, 981.

Structures

• 5JQ5: CDK2 in complex with ICEC0942

  

• 5JQ8: CDK2 in complex with ICEC0943
• 3NS9: CDK2 in complex with BS-194

  A highly specific inhibitor of CDK2. The crystal structure revealed a series of water-mediated interactions between the inhibitor and CDK2
  

• 2AVH: G4T3G4 dimeric quadruplex structure
• 2AVJ: G4(Br)UTTG4 dimeric quadruplex